A Guide to AMPK Activators
AMPK is deemed as the regulator that maintains cellular energy homeostasis that is the foundation for proper functioning of the body. In mammals, AMPK regulates the energy balance both on whole body level via response to the hormones and the brain and on cellular levels by way of sensing ATP/AMP and ATP/ADP ratio levels.
ATP is actually the most significant energy molecule present in the body. Simply put, this is where cellular function all begins. Now because of the reason that energy is used by cells, ATP breaks down into ADP that actually has got less potential for energy. Then after, ADP breaks down to AMP that has got the least energy potential among all 3. This is where AMPK steps in, it is sensing the relative ratios of ATP/ADP/AMP and telling the body if it needs more ADP so by that, it maintains proper functioning.
There are different mechanisms in which AMPK acts on. This makes sense since AMPK is the master regulator of all functioning cells. The impact of AMPK activation in our body will depend on a complicated balance of both factors as well as signaling pathways. Still, there are many different benefits of having increased AMPK and these are:
Anti aging – AMPK activation is gradually declining as we are aging. Experts actually think that AMPK is one of the contributing factors of aging. AMPK is important because it helps in having adequate level of new mitochondria and promotes cellular renewal as well.
Anti inflammation – it is interesting to know that AMPK activation helps in decreasing inflammation but this too can be decreased by inflammation.
Anti diabetic – the truth is, AMPK is becoming more and more understood when it comes to its role in diabetes treatment mainly because of the ability it has in enhancing insulin sensitivity.
There are so many herbal products/constituents as well as nutritional products that have been proven to be an effective AMPK activator and some of it include:
Number 1. AICAR – this is AMP’s analog which is required for cellular use and storage similar to ATP. Since it’s the analog of AMP, AICAR can stimulate AMPK’s activity directly which can then improve muscle performance.
Number 2. ALA – this is an abbreviation for Alpha Lipoic Acid that is a powerful AMPK activator and at the same time, popular for its effective antioxidant content. It has been shown to greatly boost insulin sensitivity in the body and carrying anti obesity effects.
Number 3. Green tea extract – this was actually discovered to help in activating AMPK by means of activating its upstream kinase.
Number 4. Berberine – not just that it is an AMPK activator, it has berberine containing metformin which is great for anti-diabetes.